422 results found
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Curated by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola et al.
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al.
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    Gurunathan Laxmikanthan et al.
    The structure of a multi-protein DNA recombination reaction intermediate reveals how regulation is achieved by protein-mediated DNA wrapping around a core enzyme-substrate complex.
    1. Computational and Systems Biology
    2. Neuroscience

    Prediction of primary somatosensory neuron activity during active tactile exploration

    Dario Campagner et al.
    Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.
    1. Developmental Biology
    2. Evolutionary Biology

    Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

    Alex de Mendoza et al.
    Functional genomics reveal complex genome regulation during the coenocytic development of the ichthyosporean Creolimax fragrantissima, a protist closely related to animals.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling

    Ariane Briegel et al.
    Bacterial cytoplasmic chemoreceptors assemble into a sandwich of two hexagonally packed arrays.
    1. Cell Biology
    2. Developmental Biology

    First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

    Guangliang Wang et al.
    A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
    1. Immunology and Inflammation

    MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway

    Hui Xu et al.
    The liver-specific miRNA microRNA-122 plays a previously unknown role in hepatocyte intrinsic innate immunity by targeting the RTKs/STAT3 signaling pathway.
    1. Cell Biology
    2. Developmental Biology

    Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

    Yuwei Li et al.
    Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.

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