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    1. Cell Biology
    2. Human Biology and Medicine

    Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

    Jianguo Wu et al.
    Overexpression of PLK1 triggers oncogenic transformation and transcriptional reprogramming of prostate epithelial cells, which stimulates cell migration and invasion.
    1. Cancer Biology

    Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

    Veronique Nogueira et al.
    Exploiting the metabolic consequences of Akt activation in prostate cancer for therapeutic interventions that circumvent Akt inhibition therapy.
    1. Cancer Biology

    Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

    Xuefei Yan et al.
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Cell Biology
    2. Human Biology and Medicine

    Prostate Cancer: SPOP the mutation

    Leah Rider, Scott D Cramer
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    1. Human Biology and Medicine

    Cancer: Designer antiandrogens join the race against drug resistance

    Jatinder S Josan, John A Katzenellenbogen
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    1. Cancer Biology
    2. Human Biology and Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus et al.
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Cell Biology
    2. Computational and Systems Biology

    Human kinetochores are swivel joints that mediate microtubule attachments

    Chris A Smith et al.
    The outer domain of the kinetochore can rotate (swivel) around the centromere, and this rather than intra-kinetochore stretching is coupled to anaphase onset.
    1. Cell Biology
    2. Human Biology and Medicine

    Cancer Metabolism: Partners in the Warburg effect

    Joshua D Rabinowitz, Hilary A Coller
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