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    1. Cell Biology
    2. Human Biology and Medicine

    Prostate Cancer: SPOP the mutation

    Leah Rider, Scott D Cramer
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    1. Human Biology and Medicine

    Cancer: Designer antiandrogens join the race against drug resistance

    Jatinder S Josan, John A Katzenellenbogen
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    1. Cell Biology
    2. Computational and Systems Biology

    Human kinetochores are swivel joints that mediate microtubule attachments

    Chris A Smith et al.
    The outer domain of the kinetochore can rotate (swivel) around the centromere, and this rather than intra-kinetochore stretching is coupled to anaphase onset.
    1. Cell Biology
    2. Human Biology and Medicine

    Cancer Metabolism: Partners in the Warburg effect

    Joshua D Rabinowitz, Hilary A Coller
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    1. Cell Biology
    2. Genes and Chromosomes

    Chromosome Segregation: Freewheeling sisters cause problems

    Takashi Akera, Michael A Lampson
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    1. Biophysics and Structural Biology
    2. Neuroscience

    Magnetogenetics: Problems on the back of an envelope

    Polina Anikeeva, Alan Jasanoff
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    1. Cancer Biology

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman et al.
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.
    1. Developmental Biology and Stem Cells

    SOX2 regulates acinar cell development in the salivary gland

    Elaine Emmerson et al.
    Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.