Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
Maxence Le Vasseur, Jonathan Friedman ... Jodi Nunnari
OCIAD1 associates with prohibitin assemblies and regulates the proteolytic processing and stability of the catalytical Complex III subunit cytochrome c1.
Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
Alison K Gillingham, Jessie Bertram ... Sean Munro
Relocation of Rab, Ras and Rho family GTPases to the surface of mitochondria enables efficient identification of their effectors, exchange factors and GAPs by proximity biotinylation.
A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
Hypobaric hypoxia exposure initiates splenic ferroptosis, reducing red pulp macrophages and exacerbating high-altitude polycythemia by impairing erythrophagocytosis and increasing red blood cell retention.
Hand somatotopy can be preserved in the primary somatosensory cortex of tetraplegic patients, despite the absence of sensorimotor function and periphery-brain communication, but deteriorates over years after injury.