97 results found
    1. Neuroscience

    Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression

    Hyun-Ji Kim et al.
    The PRMT1 protein mediates arginine methylation of KCNQ2 channels to control neuronal excitability.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani et al.
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Immunology and Inflammation

    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

    Julia M Marchingo et al.
    Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.
    1. Immunology and Inflammation

    Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

    Gabriela Krejčová et al.
    Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

    Melesse Nune et al.
    The histone chaperone FACT and the deubiquitinating enzyme Ubp10 act in concert to remove ubiquitin from histone H2B in nucleosomes, and likely coordinate nucleosome assembly during DNA replication and transcription.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.
    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

    Saumel Ahmadi et al.
    Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.
    1. Biochemistry and Chemical Biology

    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

    Andrea Pawellek et al.
    Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
    1. Neuroscience

    Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

    Silvia Ripamonti et al.
    Perturbation of oxytocin signaling causes alterations that may be causally involved in the etiology of oxytocin-related neurobehavioral disorders.

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