1,313 results found
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Biochemistry and Chemical Biology

    Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    Parnian Arafi, Sujan Devkota ... Michael S Wolfe
    Further evidence in support of a new amyloid-independent hypothesis for the pathogenesis of Alzheimer's disease is provided, with an expanded set of Alzheimer-causing mutations in the protease that produces amyloid.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Biochemistry and Chemical Biology

    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

    Prateeka Borar, Tapan Biswas ... Smarajit Polley
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Structural Biology and Molecular Biophysics

    Flexibility in PAM recognition expands DNA targeting in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
    xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G.-J Sterckx
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics

    Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice

    Minsoo Noh, Xiangguo Che ... Sihoon Lee
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    Parveen Goyal, KanagaVijayan Dhanabalan ... Subramanian Ramaswamy
    The first structure of a Neu5Ac bound Tripartite ATP-independent Periplasmic transporter (TRAP) reveals the presence of three ion binding sites.
    1. Microbiology and Infectious Disease

    On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

    Flavia A Zanetti, Ignacio Fernández ... Laura R Delgui
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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