The dynamical transition between a protein and its surface water is decoupled.

An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.

Biochemical reconstitution experiments uncover the ubiquitin-mediated function of a DNA repair protein, key to the understanding of Fanconi Anemia, a cancer-associated bone marrow failure syndrome.

Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.

Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.

Physiological studies of SLC6A17 and its pathogenic mutations revealed that glutamine is transported into synaptic vesicles (SVs) in an SLC6A17-dependent manner and all pathogenic conditions reduced glutamine level in SVs.

Life is constrained in its sampling of protein sequence space to catalyze one of the most energetically challenging biochemical reactions.

Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.