Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.
The physicochemical interactions among wild-type nucleosomes hold substantial significance and play a role in chromatin folding under physiological salt concentrations.
Yilin Kang, Michael James Baker ... Diana Stojanovski
A novel and metazoan-specific protein, Tim29, is identified as a subunit of the human TIM22 complex and shown to function in the assembly of hTim22 and facilitate contacts with the TOM complex.
The common view that the mitochondrion endowed eukaryotes with a boost in bioenergetic capacity above that in prokaryotes is inconsistent with a diversity of cellular features.
LptC regulates the LPS entry gate in LptB2FG, likely through a dynamic behavior of its transmembrane helix, while the β-jellyroll domains are tethered in the periplasm.
DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.
Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse
ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.
Dayana C Farhat, Matthew W Bowler ... Christopher Swale
The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.