1,347 results found
    1. Computational and Systems Biology

    Estimating the protein burden limit of yeast cells by measuring the expression limits of glycolytic proteins

    Yuichi Eguchi et al.
    Measurement of expression limits of yeast glycolytic proteins reveal the protein burden limit, which is the expression limit of any protein in the cell.
    1. Computational and Systems Biology

    Protein Overexpression: Reaching the limit

    Benedetta Bolognesi, Ben Lehner
    How many copies of a protein can be made before it becomes toxic to the cell?
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Hsp70-associated chaperones have a critical role in buffering protein production costs

    Zoltán Farkas et al.
    Protein biosynthesis and protein quality control jointly determine protein production costs.
    1. Structural Biology and Molecular Biophysics

    Contacts-based prediction of binding affinity in protein–protein complexes

    Anna Vangone, Alexandre MJJ Bonvin
    The number of contacts at the interface of a protein–protein complex, together with the properties of the surface, provides a simple, but well-performing predictor of binding affinity.
    1. Neuroscience

    Loss of presenilin function is associated with a selective gain of APP function

    Carole Deyts et al.
    Amyloid precursor protein expression and accumulation of its intracellular fragment are required for exuberant neurite outgrowth associated with pathological presenilin 1 loss-of-function mutations before the emergence of amyloid burden in mice.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

    Steffen Preissler et al.
    Interdomain linker-mediated oligomerization of the endoplasmic reticulum chaperone protein BiP responds to the unfolded protein burden
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Adaptive Evolution: At the mercy of viruses

    Claus O Wilke, Sara L Sawyer
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    1. Neuroscience

    Navigation: Shedding light on stellate cells

    Andrew S Alexander, Michael E Hasselmo
    The relationship between grid cells and two types of neurons found in the medial entorhinal cortex has been clarified.
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