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    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

    Marina Schrecker et al.
    Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia et al.
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Microbiology and Infectious Disease

    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

    Ashley M Ngo et al.
    The ER membrane protein complex (EMC) facilitates the correct topology of the flavivirus non-structural proteins NS4A and NS4B at the ER membrane critical for viral replication.
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn et al.
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A novel GTP-binding protein–adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

    Yusong Guo et al.
    The ability of epithelial cells to distinguish between domains on opposing cell surfaces within a tissue, a property known as planar cell polarity, relies on proteins and protein complexes directing the traffic of signaling proteins to specific locations on the cell surface membrane.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

    Nicole Merritt et al.
    The C terminal fusion partners of TAZ-CAMTA1, YAP-TFE3 and potentially other TAZ/YAP fusion proteins in cancer recruit epigenetic modifiers that modulate a baseline TEAD-based transcriptional program.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

    Sushama Sivakumar et al.
    Microtubule binding by the Spindle and Kinetochore Associated (Ska) complex concentrates protein phosphatase 1 at metaphase kinetochores to overcome the spindle checkpoint thus driving anaphase onset and mitotic exit.
    1. Cell Biology
    2. Neuroscience

    Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling

    Keqiang Xie et al.
    A G protein in striatal neurons forms preassembled complexes with its downstream enzyme, adenylyl cyclase, which has implications for the pathophysiology of movement disorders.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

    Braden T Lobingier et al.
    Sec1/Munc18 (SM) proteins shield SNARE complexes from NSF/Sec18-mediated disassembly through cooperative binding interactions with SNARE complexes and the universal co-chaperone α-SNAP/Sec17.
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.