1,340 results found
    1. Biochemistry and Chemical Biology

    Mechanism of cargo-directed Atg8 conjugation during selective autophagy

    Dorotea Fracchiolla et al.
    Autophagic cargo receptors recruit the E3-like enzyme for Atg8 lipid conjugation to the cargo and thereby promote local formation of Atg8-positive autophagosomal membranes.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink et al.
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat et al.
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

    Masashi Watanabe et al.
    TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing the PPARγ protein.
    1. Neuroscience

    Analysis of SUMO1-conjugation at synapses

    James A Daniel et al.
    Analyses using His6-HA-SUMO1 and SUMO1 KO mice indicate that SUMO1 modification of synaptic proteins is either absent or cannot be detected in brain and cultured neurons.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim et al.
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

    Spencer Hill et al.
    Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang et al.
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Genetics and Genomics
    2. Neuroscience

    Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay

    Myungjin Kim et al.
    A genetic mutation that impairs autophagic flux leads to neurodegeneration and can cause ataxia and developmental delay in children.
    1. Cell Biology

    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

    Rui Jia, Juan S Bonifacino
    An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.

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