2,106 results found
    1. Cell Biology

    G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

    Tao Zhang et al.
    Under normal nutritional conditions, G-protein coupled receptors can control autophagy by regulating the degradation of key autophagic regulator Atg14L through ZBTB16-mediated ubiquitination and proteasome degradation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson et al.
    Messenger RNA degradation alters protein trafficking to control transcription.
    1. Cell Biology

    Mitochondria: Selective protein degradation ensures cellular longevity

    Sandra Malmgren Hill, Thomas Nyström
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    1. Structural Biology and Molecular Biophysics

    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

    Zev A Ripstein et al.
    Understanding of bacterial protein degradation is illuminated by cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution.
    1. Cell Biology

    Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

    Adam L Hughes et al.
    A new mitochondrial protein degradation pathway selectively sorts and destroys a subset of the mitochondrial membrane proteome to protect mitochondria in times of stress.
    1. Neuroscience

    Enhancement of fear memory by retrieval through reconsolidation

    Hotaka Fukushima et al.
    Retrieval enhances fear memory through reconsolidation by activating calcineurin-induced protein degradation and CREB-mediated gene expression in amygdala, hippocampus, and mPFC.
    1. Neuroscience

    Proteome dynamics during homeostatic scaling in cultured neurons

    Aline Ricarda Dörrbaum et al.
    Dynamic SILAC labeling in combination with mass spectrometry revealed substantial regulation of protein synthesis, degradation, turnover, and abundance during homeostatic scaling in neurons.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

    Luis V Nobre et al.
    The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
    1. Cell Biology
    2. Developmental Biology

    Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

    Alexander D Fulford et al.
    The tissue growth controlling Hippo signalling pathway is modulated by the activity of the Casein Kinase 1 family, which regulates the protein stability of the upstream Hippo pathway component Expanded.

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