24 results found
    1. Biochemistry and Chemical Biology

    Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

    Nadinath B Nillegoda et al.
    The emergence of complementary electrostatic potentials after the prokaryotic-to-eukaryotic split drives physical and functional cooperation between canonical class A and class B J-proteins to boost protein disaggregation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Biochemistry and Chemical Biology

    Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation

    Agnieszka Kłosowska et al.
    Hsp70 chaperone provides Hsp104 with high efficiency in disaggregation and specificity towards aggregated substrates at the, otherwise limiting, cellular concentrations of adenine nucleotides.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the disaggregase activity and regulation of Hsp104

    Alexander Heuck et al.
    Protein disaggregases employ two mechanically-linked ATPase rings that are under steric control by a wrapped-around coiled-coil belt.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

    Marta Carroni et al.
    Overcoming image-processing problems in the analysis of the ClpB chaperone provides a new structural model and regulatory mechanism, based on clear density for the coiled-coil domain and supported by various biochemical data.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.

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