171 results found
    1. Structural Biology and Molecular Biophysics

    A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

    Anne K Schuetz, Lewis E Kay
    Point mutations in a ubiquitous human ATPase called p97/VCP deregulate inter-domain communication, resulting in impaired binding of an adaptor that recruits p97 to endosomal pathways and leading to a degenerative disease of bone, muscle and neurons.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin et al.
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Genetics and Genomics

    On the mechanistic nature of epistasis in a canonical cis-regulatory element

    Mato Lagator et al.
    Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    Yong Wang et al.
    Molecular simulations can capture key aspects of the conformational exchange in a protein.
    1. Structural Biology and Molecular Biophysics

    Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

    Marina A Kasimova et al.
    The gating polarity of a voltage-gated ion channel is primarily determined by turn propensity of residues at a critical position in the middle of the S4 voltage-sensing helix.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

    James Chen et al.
    Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

    Adriana E Golding et al.
    Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

    Robin A Corey et al.
    How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Ion counting demonstrates a high electrostatic field generated by the nucleosome

    Magdalena Gebala et al.
    First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.
    1. Biochemistry and Chemical Biology

    A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

    Ruben M Atilho et al.
    Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.

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