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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

    Ravi Kant et al.
    Hydrogen-Deuterium exchange experiments show that Ric-8A induces similar dynamic changes in the structure of Gα as G protein-coupled receptors, yet protects a larger surface of the nucleotide-binding Ras domain.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

    Xianqiang Sun et al.
    Combining powerful simulation methods uncovers the structural and dynamical changes driving G protein activation in atomic detail, revealing the allosteric network that triggers GDP release and reconciling diverse experimental data.
    1. Structural Biology and Molecular Biophysics

    Microsecond sub-domain motions and the folding and misfolding of the mouse prion protein

    Rama Reddy Goluguri et al.
    Native state dynamics of mouse prion protein were measured, and these motions were shown to be having a role in initiation of aggregation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang et al.
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Chromosomes and Gene Expression

    Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression

    Stefan Meinke et al.
    Competition between minor and major splice sites in SRSF10 controls cell type-dependent expression of all SR-proteins and reveals a global impact of the minor spliceosome on major intron splicing.
    1. Cell Biology

    Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification

    Parisa Asghari et al.
    Repositioning the type II ryanodine receptors on the sarcoplasmic reticulum membrane is a potential new mechanism regulating their function, and therefore the strength of cardiac contraction.
    1. Microbiology and Infectious Disease

    An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics

    Prahathees J Eswara et al.
    GpsB in Staphylococcus aureus directly regulates the central cell division protein FtsZ, a different function from that assigned for GpsB in other closely related organisms.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

    Ajay Mishra et al.
    A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

    Piyali Saha et al.
    Molecular analysis of cholesterol transport by NPC1 and NPC1L1 proteins reveals that cholesterol likely moves through these transporters, and ezetimibe blocks NPC1L1 by binding at the interface between multiple domains.
    1. Cell Biology
    2. Physics of Living Systems

    Single-molecule turnover dynamics of actin and membrane coat proteins in clathrin-mediated endocytosis

    Michael M Lacy et al.
    The main proteins of clathrin-mediated endocytosis bind and unbind rapidly, continuously turning over about five times during the formation of an endocytic vesicle in yeast.