8,502 results found
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey et al.
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Cell Biology
    2. Plant Biology

    Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import

    Yamuna D Paila et al.
    The conserved polypeptide transport associated (POTRA) domains of the protein import channel, Toc75, are essential for protein import into chloroplasts.
    1. Cell Biology

    Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

    Xun X Bao et al.
    Microtubule nucleation from the nuclear envelope in fission yeast involves repurposing of nuclear export proteins for a non-export-related function, docking cytoplasmic proteins at nuclear pore complexes.
    1. Chromosomes and Gene Expression

    A nuclear role for the DEAD-box protein Dbp5 in tRNA export

    Azra Lari et al.
    Within the nucleus, Dbp5p supports tRNA export providing a parallel mechanism by which this conserved DEAD-box protein functions to support eukaryotic gene expression.
    1. Biochemistry and Chemical Biology

    Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

    Valentina Peleh et al.
    The import of proteins into the intermembrane space of mitochondria is driven by binding to the trans-site receptor Mia40 and not by the oxidation of cysteine residues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

    Niels Denkert et al.
    Channel characteristics of the presequence translocation pore have a direct impact on protein import into the mitochondrial matrix.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

    Bhargavi Jayaraman et al.
    A pliable hydrophobic interface in the HIV-1 Rev protein enables assembly of diverse oligomeric structures, guided by the RRE scaffold present in HIV-1 mRNAs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz et al.
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.
    1. Cell Biology
    2. Neuroscience

    C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

    Lindsey R Hayes et al.
    Poly-PR and poly-GR interact with importin β, disrupt importin-cargo loading, and inhibit nuclear import in permeabilized cells in a manner that can be rescued by RNA.
    1. Genetics and Genomics

    Genetic profiling of protein burden and nuclear export overload

    Reiko Kintaka et al.
    A comprehensive analysis of yeast mutants has provided clues to understanding the physiological conditions caused by protein overexpression.

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