6,366 results found
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer et al.
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Cell Biology
    2. Neuroscience

    The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

    Anna L Chaly et al.
    A non-melanocortin G-protein coupled receptor is inhibited by the Melanocortin Receptor Accessory Protein 2 (MRAP2) to control food intake in mammals.
    1. Cell Biology

    Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

    Mario Ruiz et al.
    Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

    Sonya Entova et al.
    Key sequence motifs, defined using the first reported structure of a monotopic membrane protein with a reentrant helix, enable identification of new monotopic membrane protein families previously predicted as membrane spanning.
    1. Neuroscience

    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Eiko Iwakoshi-Ukena et al.
    Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor

    Xinyun Cao et al.
    An unexpected new biological function was discovered for the universally conserved cofactor lipoate, as lipoate-binding proteins proved essential for a novel wide-spread prokaryotic sulfur oxidation pathway.
    1. Neuroscience

    Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation

    Marieke MB Hoekstra et al.
    The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Large-scale determination of previously unsolved protein structures using evolutionary information

    Sergey Ovchinnikov et al.
    A new method of protein structure prediction that incorporates residue–residue co-evolution information into the Rosetta structure prediction program was used to develop models for 58 large protein families that had no previous structural information.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins

    Meghan Whitney Franklin et al.
    There is a strand-based evolutionary mechanism for the diversification of outer membrane proteins, which has implications for how repeat proteins are created and for how outer membrane proteins fold.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.

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