Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
Cell-type-specific ribosome profiling during prion disease progression identified minor translational changes in neurons as well as profound glia changes many of which are shared with other neurodegenerative diseases.
Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition significantly delays both prostate and skin tumor progression.
Characterization of a novel population of enteric nervous system glial cells in zebrafish reveals their proliferative and neurogenic properties under homeostatic conditions in adults, properties difficult to model in mammals.