8,070 results found
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey et al.
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Cell Biology
    2. Plant Biology

    Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import

    Yamuna D Paila et al.
    The conserved polypeptide transport associated (POTRA) domains of the protein import channel, Toc75, are essential for protein import into chloroplasts.
    1. Cell Biology
    2. Neuroscience

    C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

    Lindsey R Hayes et al.
    Poly-PR and poly-GR interact with importin β, disrupt importin-cargo loading, and inhibit nuclear import in permeabilized cells in a manner that can be rescued by RNA.
    1. Cell Biology

    A nuclear-based quality control pathway for non-imported mitochondrial proteins

    Viplendra PS Shakya et al.
    During times of mitochondrial impairment, non-imported mitochondrial precursor proteins are targeted to the nucleus for proteasome-dependent degradation.
    1. Chromosomes and Gene Expression

    A nuclear role for the DEAD-box protein Dbp5 in tRNA export

    Azra Lari et al.
    Within the nucleus, Dbp5p supports tRNA export providing a parallel mechanism by which this conserved DEAD-box protein functions to support eukaryotic gene expression.
    1. Biochemistry and Chemical Biology

    Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

    Valentina Peleh et al.
    The import of proteins into the intermembrane space of mitochondria is driven by binding to the trans-site receptor Mia40 and not by the oxidation of cysteine residues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

    Niels Denkert et al.
    Channel characteristics of the presequence translocation pore have a direct impact on protein import into the mitochondrial matrix.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz et al.
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.
    1. Genetics and Genomics

    Genetic profiling of protein burden and nuclear export overload

    Reiko Kintaka et al.
    A comprehensive analysis of yeast mutants has provided clues to understanding the physiological conditions caused by protein overexpression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

    Rupa Banerjee et al.
    Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.

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