2,564 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

    Melissa Kane et al.
    Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.
    1. Cell Biology

    Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

    Yubing Liu et al.
    Embryonic development requires autophagy-dependent degradation of ribosomal RNAs.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human axial progenitors generate trunk neural crest cells in vitro

    Thomas JR Frith et al.
    Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.
    1. Biochemistry and Chemical Biology

    A discriminator code–based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria

    Santosh Kumar Kuncha et al.
    Using bioinformatic and biochemical approaches, the study has explained the discriminator base anomaly in bacterial tRNA(Gly) through identification of the key determinant of DTD specificity.
    1. Chromosomes and Gene Expression

    Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

    Zheng Hu et al.
    Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
    1. Biochemistry and Chemical Biology

    An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast

    Jackie Lang et al.
    An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.
    1. Microbiology and Infectious Disease

    Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection

    Kinjal Majumder et al.
    Development of a generally adaptable conformational capture assay for use in-trans identifies the specific direct interaction sites between the parvovirus minute virus of mice and the cellular genome during infection as sites of cellular DNA damage.
    1. Genetics and Genomics

    An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila

    David Li-Kroeger et al.
    New technology for manipulating genes in Drosophila facilitates gene tagging and precise modification of virtually any gene.
    1. Evolutionary Biology

    A multispecies coalescent model for quantitative traits

    Fábio K Mendes et al.
    A model for evolutionary inferences at both micro- and macroevolutionary scales is proposed and evaluated theoretically and through simulations.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of alpha-synuclein fibrils

    Ricardo Guerrero-Ferreira et al.
    The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.

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