2,937 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

    Jorge M Santos et al.
    A small surface protein regulates gliding motility and host cell invasion by the sporozoite stage of the malaria parasite.
    1. Cell Biology

    TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

    Hiroaki Ishikawa et al.
    Loss of one protein from the intraflagellar transport complex leads to a defect in import of a specific sub-set of proteins into the flagellum.
    1. Biochemistry and Chemical Biology

    Intracellular Diffusion: How bacteria keep proteins moving

    Conrad W Mullineaux
    Bacteria contain large numbers of negatively-charged proteins to avoid the electrostatic interactions with ribosomes that would dramatically reduce protein diffusion.
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    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang et al.
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

    Courtney M Schroeder et al.
    The dynein light intermediate chain is a member of the G protein superfamily and links the motor to several intracellular cargo adaptors.
    1. Biochemistry and Chemical Biology

    Ribosome surface properties may impose limits on the nature of the cytoplasmic proteome

    Paul E Schavemaker et al.
    The diffusion coefficients of proteins in the cytoplasm depend on their net charge and the distribution of charge over the protein surface, with positive proteins moving up to 100-fold slower because they bind to ribosomes.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Motility precedes egress of malaria parasites from oocysts

    Dennis Klug, Friedrich Frischknecht
    A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

    Diana C Rodriguez Camargo et al.
    The ability of lipid nanodiscs to trap different types of amyloid intermediates, as successfully demonstrated in this study for human-IAPP, could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
    1. Biophysics and Structural Biology

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira et al.
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.

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