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    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Cell Biology

    Pericentrin-mediated SAS-6 recruitment promotes centriole assembly

    Daisuke Ito et al.
    Newly discovered interaction between fission yeast SPB and animal centriole components reveals that pericentrin not only functions as a microtubule-nucleator, but also promotes centriole assembly in animals.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

    Tom Killelea et al.
    An investigation into 8-oxodeoxguanosine bypass by archaeal DNA polymerases.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

    Snježana Mikuličić et al.
    ADAM17 is a key player in the non-canonical endocytosis pathway that is used by oncogenic papillomaviruses as it allows virus/receptor platform assembly by activation of the ERK1/2 signaling pathway.
    1. Plant Biology

    Plant–necrotroph co-transcriptome networks illuminate a metabolic battlefield

    Wei Zhang et al.
    Simultaneously measuring the transcriptomes of both a host plant and fungal pathogen, co-transcriptomics, identified diverse, dynamic and independent communication mechanisms conveying information between the two organisms via discrete gene modules.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Synergy between serum amyloid A and secretory phospholipase A2

    Shobini Jayaraman et al.
    SAA removes toxic products of lipolysis of the cell membrane by sPLA2, indicating that SAA and sPLA2 act synergistically to clear debris from injured sites, as required for tissue healing.
    1. Microbiology and Infectious Disease

    Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

    Andrew Tze Fui Liew et al.
    Inside the acidic vacuole, expression, DNA binding and DNA binding affinity of the Salmonella regulator SsrB is stimulated by acid pH.
    1. Cell Biology

    Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

    Jenna R Christensen et al.
    The contractile ring actin binding proteins tropomyosin Cdc8 and a-actinin Ain1 synergize to effectively compete with the endocytic actin patch protein fimbrin Fim1 for associating with F-actin networks.
    1. Neuroscience

    Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

    Ernesto Manzo et al.
    Degenerating motor neurons compensate for energetic deficits by upregulating glycolysis in flies and humans, with increased glucose availability improving locomotor function and lifespan in flies.
    1. Neuroscience

    Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling

    Thomas D James et al.
    Synapses employ distinct acute and chronic signaling processes in order to maintain physiologically appropriate levels of function.