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    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller et al.
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Structural Biology and Molecular Biophysics

    Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

    Iordan Iordanov et al.
    Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR), whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

    Kathryn Geiger-Schuller et al.
    Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.
    1. Stem Cells and Regenerative Medicine

    Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

    Emily J Lodge et al.
    The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Developmental Biology
    2. Neuroscience

    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

    Hirofumi Noguchi et al.
    Sufu controls dentate gyrus stem cell quiescence by acting as a positive regulator of Shh signaling and loss of Sufu leads to dramatic failure to produce sufficient quiescent stem cells.
    1. Cell Biology
    2. Genetics and Genomics

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Nicolas J Lehrbach, Gary Ruvkun
    SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Panton–Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

    Bernadette C Young et al.
    Genome-wide association studies have established staphylococcal pyomyositis as a disease whose pathogenesis depends critically on expression of a single toxin, Panton–Valentine leukocidin.
    1. Neuroscience

    Generalization of learned responses in the mormyrid electrosensory lobe

    Conor Dempsey et al.
    In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.
    1. Neuroscience

    Valence-encoding in the lateral habenula arises from the entopeduncular region

    Hao Li et al.
    Lateral habenula neurons participate in motivated behavior via their activation by negative affective stimuli, a major source of which arises from the rostral entopeduncular nucleus.