690 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

    Rupa Banerjee et al.
    Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

    William John Allen et al.
    Evidence is presented that supports a completely new, diffusion-driven mechanism for transporting proteins across membranes in bacteria.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A functional link between the co-translational protein translocation pathway and the UPR

    Rachel Plumb et al.
    Ire1α co-opts the Sec61 translocon channel to efficiently cleave its mRNA substrates during endoplasmic reticulum stress conditions.
    1. Cell Biology

    Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

    Keigo Araki et al.
    TNF-α treatment induces phosphorylation and cytoplasmic translocation of the retinoblastoma protein, which regulates cytoskeletal organization in skeletal muscle cells.
    1. Structural Biology and Molecular Biophysics

    Dynamic action of the Sec machinery during initiation, protein translocation and termination

    Tomas Fessl et al.
    The complex process of protein translocation across membranes has been dissected into multiple key steps and the distributions of translocation rates indicate stochastic nature of the reaction.
    1. Biochemistry and Chemical Biology

    Kinetics of initiating polypeptide elongation in an IRES-dependent system

    Haibo Zhang et al.
    The retarding effect of a ribosome-bound internal ribosome entry site on eukaryotic protein synthesis is largely overcome following translocation of tripeptidyl-tRNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of proton translocation and force generation in mitochondrial ATP synthase

    Niklas Klusch et al.
    Cryo-EM reveals atomic details of two membrane half-channels for translocation of protons that drive rotary catalysis in ATP synthase.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

    Nicole Monroe et al.
    A cryo-electron microscopy structure of a substrate-bound Vps4-Vta1 AAA ATPase reveals an asymmetric hexameric ring and suggests how nucleotide-induced changes in subunit interfaces translocate polypeptides into the central pore.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

    Erik Lee Snapp et al.
    Signal-peptide cleavage of HIV-1 envelope glycoprotein is delayed because of alpha-helical structure covering the cleavage site, effecting early cleavage alters the folding pathway and resulting in localized misfolding and reduced viral fitness.

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