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    1. Neuroscience

    A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

    Matthias Siebert et al.
    High affinity interactions with transport adaptors are important to shield the interaction surfaces of cytomatrix components to block fatal premature oligomerization of active zone proteins during axonal transport.
    1. Cell Biology

    Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae

    Galina V Beznoussenko et al.
    The soluble cargo protein albumin traverses the Golgi stack at much faster rates than procollagen aggregates, by diffusion via intercisternal continuities.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

    Piyali Saha et al.
    Molecular analysis of cholesterol transport by NPC1 and NPC1L1 proteins reveals that cholesterol likely moves through these transporters, and ezetimibe blocks NPC1L1 by binding at the interface between multiple domains.
    1. Cell Biology
    2. Neuroscience

    Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

    Junjun Zhao et al.
    Two homologous kinesin motors, KIF5A and KIF5B, have distinct functions in dendritic spine morphogenesis, and KIF5B plays a role in synaptic plasticity and memory.
    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller et al.
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

    Mehabaw G Derebe et al.
    Serum amyloid A proteins bind retinol with nanomolar affinity, and do so by forming oligomers that create a hydrophobic pocket that shields retinol from the aqueous environment.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

    Marina Schrecker et al.
    Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

    Thomas Pohlmann et al.
    An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
    1. Structural Biology and Molecular Biophysics

    Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations

    Maureen Leninger et al.
    Conservative mutations within a secondary active transport protein influenced the conformational equilibrium probed using NMR spectroscopy which correlated to the functional output in vivo.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter et al.
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.