1,368 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding

    Tristan A Bell et al.
    The AAA+ protein unfolding motor ClpX grips substrates with the uppermost part of its substrate-binding pore, and requires interactions with hydrophobic amino acid side chains to operate with optimal efficiency.
    1. Cell Biology

    Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

    Satoshi Tsunoda et al.
    Adapting a cytosolic enzyme that breaks down glutathione to function in the lumen of the endoplasmic reticulum challenges the long-held view that reduced glutathione fuels disulfide rearrangements during protein folding.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding

    Hao Wang et al.
    N-glycans commonly present in the protease domains are required for calnexin-mediated protein folding and intracellular trafficking.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

    Robin A Corey et al.
    How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
    1. Structural Biology and Molecular Biophysics

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

    Renuka Kudva et al.
    Proteins can fold deeper inside ribosomes with an enlarged exit tunnel.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tracing a protein’s folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange

    Shion An Lim et al.
    Pulsed-labeling hydrogen exchange on the ribonuclease H family show that the major folding intermediate is conserved over three billion years of evolution, but the path leading to this intermediate varies.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu et al.
    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    C-mannosylation supports folding and enhances stability of thrombospondin repeats

    Aleksandra Shcherbakova et al.
    C-mannosylation supports native folding of thrombospondin type 1 repeats in the endoplasmic reticulum and stabilizes the folded proteins by modulating the dynamics of the tryptophan-arginine ladder.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.

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