Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.

In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.

Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.

The Polycomb group protein SCML2 contributes to the assembly and gene silencing function of Polycomb Repressive Complex 1 (PRC1) and requires an RNA-binding region to reach chromatin targets.

A bacteriophage remodels the RNA metabolism machinery of a bacterial host to sequentially clear host transcripts and then stabilize the viral RNA.

A comprehensive study of human transcription factors reveals that a greater number of these proteins bind to methylated DNA sequences than previously thought.

Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.

By moving between DNA segments like a child swinging on monkey bars, poly(ADP-ribose) polymerase 1 explores possible DNA damage sites more effectively.

The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.