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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex

    Jordan D Carelli, Steven G Sethofer ... Jack Taunton
    An ancient complex comprising the eukaryotic elongation factor-1A and aminoacylated tRNA is shown to be the target of a cyclic heptapeptide and two unrelated natural products with potent anticancer activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

    Steffen Preissler, Joseph E Chambers ... David Ron
    Interdomain linker-mediated oligomerization of the endoplasmic reticulum chaperone protein BiP responds to the unfolded protein burden
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