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    1. Neuroscience

    Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity

    Anjali Bisht, Srikanth Pippadpally ... Vimlesh Kumar
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Developmental Biology

    Neuroprotective role of Hippo signaling by microtubule stability control in C. elegans

    Hanee Lee, Junsu Kang ... Junho Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

    Pyae Hein Htet, Edward Avezov, Eric Lauga
    The viscous hydraulics of contracting endoplasmic reticulum networks challenge common solute transport theories, suggesting the contraction of peripheral sheets as a plausible driving mechanism.
    1. Developmental Biology

    Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

    Max Henry Hills, Limei Ma ... C Ron Yu
    A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
    1. Neuroscience

    The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells

    Hannah R Martin, Anna Lysakowski, Ruth Anne Eatock
    A striking and consequential conductance in vestibular type I hair cells is finally shown to depend on a little-known Shaker subunit that contributes to conventional conductances in other hair cells.
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas J Roberts
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Cancer Biology

    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

    Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

    Matias A Medina, Francisco Fuentes-Villalobos ... Maria Ines Barria
    Longitudinal transcriptomic analysis of unvaccinated patients reveals that early NK cell cytotoxicity activation distinguishes mild from severe COVID-19, supporting the relevance of concerted innate–adaptive immune responses against the virus.
    1. Cell Biology

    Secreted exosomes induce filopodia formation

    Caitlin McAtee, Mikin Patel ... Alissa M Weaver
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing