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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

    Damien Detraux, Marino Caruso ... Patricia Renard
    Accumulation of succinate during the in vitro modeling of embryonic stem cell state transition critically regulate cell fate.
    1. Neuroscience

    Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues

    Julieta E Lischinsky, Katie Sokolowski ... Joshua G Corbin
    Studying the development of the medial amygdala in the mouse reveals how the brain may potentially process sex differences in innate behaviors such as mating.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski, Luke E Berchowitz ... Ian R Henderson
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.
    1. Neuroscience

    Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

    Linda H Kim, Adam Lognon ... Patrick J. Whelan
    Not revised
    Reviewed Preprint v1
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    1. Ecology

    Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

    Yang Ruan, Ning Ling ... Zhibiao Nan
    Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
    1. Cell Biology

    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

    Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry
    Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
    1. Immunology and Inflammation

    Amphibian mast cells serve as barriers to chytrid fungus infections

    Kelsey A Hauser, Christina N Garvey ... Leon Grayfer
    Enriching amphibian, Xenopus laevis, cutaneous mast cells confers protection against Batrachochytrium dendrobatidis chytrid fungus infections.
    1. Ecology

    Plant-associated CO2 mediates long-distance host location and foraging behaviour of a root herbivore

    Carla CM Arce, Vanitha Theepan ... Ricardo AR Machado
    The larvae of the western corn rootworm use root-emitted CO2 to successfully locate the most suitable host plant.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

    Reem Abdel-Haq, Johannes CM Schlachetzki ... Sarkis K Mazmanian
    Microbiome-diet interactions shape microglia reactivity in a mouse model of Parkinson's disease.
    1. Structural Biology and Molecular Biophysics

    Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

    Nicole Toepfner, Christoph Herold ... Jochen Guck
    The morphology and deformability of all blood cells can be measured continuously and with high throughput directly in whole blood without prior enrichment or separation.
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