2,227 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

    Huy Quoc Nguyen et al.
    A novel high-throughput method for measuring many weak protein-peptide affinities simultaneously reveals how calcineurin, a human phosphatase essential for the immune response, recognizes its peptide substrates.
    1. Genetics and Genomics

    Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

    Manon Baëza et al.
    Short peptide motifs can confer specificity to developmental networks by inhibiting protein–protein interactions.
    1. Structural Biology and Molecular Biophysics

    Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

    Dan Tan et al.
    An enrichable cross-linker with optional isotope labeling quadruples the number of cross-linked peptides identified from high-complexity samples, enhancing proteome-wide analysis of protein-protein interactions and protein conformational changes by mass spectrometry.
    1. Developmental Biology
    2. Neuroscience

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor et al.
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Evolutionary Biology

    Neuropeptide Signaling: Unravelling the evolutionary history of kisspeptin

    Maria I Arnone, Paola Oliveri
    Experiments in sea cucumbers reveal how the physiological responses regulated by a neuropeptide called kisspeptin have evolved.
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    1. Developmental Biology
    2. Genetics and Genomics

    Aging and Longevity: Short and sweet

    Coleen T Murphy
    A truncated version of the only insulin receptor in C. elegans has been discovered.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Aging: A new defense in the battle of the sexes

    George L Sutphin
    Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.
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    1. Structural Biology and Molecular Biophysics

    Ion Channels: Exploiting natural regulation

    Catherine Proenza
    Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mitosis: Checkpoint proteins come under scrutiny

    Maria Mora-Santos, Jonathan BA Millar
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