7 results found
    1. Computational and Systems Biology

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Cell Biology

    One-shot analysis of translated mammalian lncRNAs with AHARIBO

    Luca Minati et al.
    Detection of translated lncRNAs through selective isolation of active ribosomes, ribosome-associated RNAs and corresponding de novo synthesised peptides.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins

    Sondos Samandi et al.
    Conventional annotations of coding sequences have missed thousands of short open-reading frames encoding proteins that are conserved and with specific functions.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

    Anil Raj et al.
    Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
    1. Genetics and Genomics

    Population-scale proteome variation in human induced pluripotent stem cells

    Bogdan Andrei Mirauta et al.
    Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels

    Lizbeth Sayavedra et al.
    Beneficial symbiotic bacteria encode an exceptional number of toxin-related genes that are all expressed by the symbionts in the host, supporting their key role in host-microbe interactions.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals

    Eric M Sanford et al.
    When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.

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