793 results found
    1. Cell Biology
    2. Developmental Biology

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder et al.
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Neuroscience

    Proteolytic maturation of α2δ controls the probability of synaptic vesicular release

    Laurent Ferron et al.
    Proteolytic maturation of auxiliary α2δ subunits of voltage-gated calcium channels increases neuronal communication by controlling the synaptic release of neurotransmitter.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

    Ivan Kadurin et al.
    Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP

    Debashree Chatterjee et al.
    Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.
    1. Developmental Biology

    Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates

    Michael W Susman et al.
    Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Structural Biology and Molecular Biophysics

    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

    Sigrid Noreng et al.
    The in-depth structural and functional work provide a deeper understanding as to how the epithelial sodium channel is a heteromeric ion channel that is regulated by Na+ and proteolysis.
    1. Structural Biology and Molecular Biophysics

    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

    Zev A Ripstein et al.
    Understanding of bacterial protein degradation is illuminated by cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

    Sora Kim et al.
    Crosslinking the AAA+ protease interface does not abolish protein degradation by ClpAP, establishing that rotation of the AAA+ unfoldase with respect to its partner peptidase is not essential for activity.

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