61 results found
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon et al.
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Microbiology and Infectious Disease

    Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

    Maria Eugenia Dieterle et al.
    Several previously proposed cell-surface receptors for hantaviruses could be deleted in endothelial cells with little or no effect on infection, indicating that critical hantavirus entry factors remain undiscovered.
    1. Immunology and Inflammation
    2. Neuroscience

    Sensing the world and its dangers: An evolutionary perspective in neuroimmunology

    Aurora Kraus et al.
    The investigation of neuroimmunology in non-model organisms is critical to diversify the field and identify primordial principles that govern neuroimmune communication across taxa.
    1. Cell Biology
    2. Developmental Biology

    Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription

    Sherzod A Tokamov et al.
    Kibra-mediated Hippo complex assembly promotes Kibra degradation in a negative feedback loop that is regulated by mechanical tension.
    1. Neuroscience

    Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

    David Exposito-Alonso et al.
    Neuregulins control the integration of specific excitatory and inhibitory synapses through subcellular sorting.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

    Kyaw Thu Minn et al.
    Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
    1. Developmental Biology
    2. Genetics and Genomics

    Smchd1 is a maternal effect gene required for genomic imprinting

    Iromi Wanigasuriya et al.
    Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
    1. Developmental Biology
    2. Neuroscience

    Cadherins regulate nuclear topography and function of developing ocular motor circuitry

    Athene Knüfer et al.
    Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.
    1. Genetics and Genomics

    Beyond the RNA-dependent function of LncRNA genes

    Tamer Ali, Phillip Grote
    Recent examples demonstrate that already the transcriptional activity at lncRNA genes does have an important function on gene regulation, while the produced non-coding RNA might be dispensable.
    1. Genetics and Genomics
    2. Medicine

    Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

    Jeanne L Theis et al.
    Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.

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