1,758 results found
    1. Cell Biology

    A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

    Ka Man Carmen Chan et al.
    A viral fusogen drives cell-cell fusion by hijacking the actin machinery to directly couple actin assembly with a short fusogenic ectodomain.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara et al.
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lipid accumulation controls the balance between surface connection and scission of caveolae

    Madlen Hubert et al.
    Caveolae sense the membrane lipid composition, which influences their dynamic behavior at the cell surface.
    1. Neuroscience

    LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina

    Courtney A Burger et al.
    LKB1 instructs the timing and location of synapse layer emergence in the outer retina by coordinating the regulation of pre- and postsynaptic neuron maturation and transport of synapse-associated proteins.
    1. Neuroscience

    Acetylcholine acts on songbird premotor circuitry to invigorate vocal output

    Paul I Jaffe, Michael S Brainard
    The neuromodulator acetylcholine contributes to state-dependent modulation of motor vigor and variability by direct action on songbird premotor cortex, bypassing basal ganglia circuitry.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

    Mounir El Maï et al.
    Telomere shortening with age promotes a switch from p53-dependent apoptosis to senescence prompted by tissue damage that triggers conflicting mTOR/AKT signalling, lower OxPhos defences and ROS, mitochondria dysfunction and senescence.
    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson et al.
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Structural Biology and Molecular Biophysics

    Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

    Cristina Olivieri et al.
    A combination of NMR, fluorescence, and molecular dynamics simulations reveals the recognition mechanism for the intrinsically disordered regulator of protein kinase A, highlighting the enzyme's nuclear export process.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

    Oliver W Bayfield et al.
    Structure of the portal protein of a thermostable virus, determined in its capsid-bound state, reveals a molecular mechanism that prevents DNA slippage during genome packaging.
    1. Microbiology and Infectious Disease

    Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii

    Nicolò Tosetti et al.
    A combination of high-resolution microscopy and reverse genetics identified key components of the alveolin network playing an essential role in the assembly of subpellicular microtubules and conoid in Toxoplasma gondii..

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