987 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A single K+-binding site in the crystal structure of the gastric proton pump

    Kenta Yamamoto et al.
    Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

    Thomas Eicher et al.
    A transport mechanism is uncovered in the major drug-efflux system in E. coli involving two remote alternating-access conformational cycles, which could provide the basis for the development of allosteric inhibitors against multidrug resistance.
    1. Structural Biology and Molecular Biophysics

    An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

    Zhao Wang et al.
    The tripartite drug efflux pump AcrA-AcrB-TolC, representative of a wide group of pumps from Gram-negative bacteria, enters a transport-competent state through long-distance conformational changes that switch the channel from a closed to an open state.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Evolutionary Biology
    2. Neuroscience

    A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

    Christian Damsgaard et al.
    A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba et al.
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Cell Biology

    Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

    Fang-Min Lu et al.
    Transient Ca elevations of cytoplasmic calcium in cardiac myocytes profoundly activate cardiac Na/K pump activity in parallel with physical-chemical changes of the sarcolemma but without involvement of conventional signaling mechanisms.
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh et al.
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

    Mei-Jung Lin et al.
    Reoxygenation of anoxic cardiac tissue promotes massive endocytosis that is triggered by release of coenzymeA from mitochondria, followed by palmitoylation of membrane proteins, sarcolemma vesiculation, and transfer of sarolemma vesicles to large endosomes and vacuoles.

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