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Selective rab11 transport and the intrinsic regenerative ability of CNS axons
Hiroaki Koseki et al.
Mature axons lose the ability to regenerate because key growth molecules are excluded through changes in vesicle transport, and restoring transport can restore regeneration.
Prickle isoforms determine handedness of helical morphogenesis
Bomsoo Cho et al.
isoforms of the Prickle protein determine right- or left-handed bristle morphogenesis by coupling Frizzled/Vang signaling to the Fat/Dachsous PCP directional signal in opposite directions.
Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse
Sooyun Kim et al.
A novel mechanism of local plasticity in the distal dendrites of hippocampal granule cells.
Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion
Holly Hardy et al.
Chick optic fissure closure is a powerful new model system for epithelial fusion and has revealed Netrin-1 as a conserved and essential mediator of tissue fusion in multiple contexts.
Stem Cells and Regenerative Medicine
GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool
ChangHwan Lee et al.
Analyzing the readout of Notch signaling with single RNA precision reveals that active transcription sites are the most accurate measure of Notch-dependent transcriptional activation.
Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb
Jenelle Wallace et al.
Adult-born neurons in the olfactory bulb that develop in the absence of microglia have a higher density of small spines but weaker excitatory inputs and reduced responses to sensory stimuli.
An intrinsic cell cycle timer terminates limb bud outgrowth
Joseph Pickering et al.
Size control in limbs is an intrinsically determined process.
A shift in anterior–posterior positional information underlies the fin-to-limb evolution
Koh Onimaru et al.
A shift in antero-posterior positional information may contribute to the fin-to-limb transformation.
Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development
Sruthi Purushothaman et al.
While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
Coordination of planar cell polarity pathways through Spiny-legs
Abhijit A Ambegaonkar, Kenneth D Irvine
A direct connection between distinct planar cell polarity systems orients cells, answering long-standing questions regarding the relationship between systems and the orientation of cell polarity.
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