27 results found
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

    Alan Sulpizio et al.
    The pseudokinase-like Legionella effector SidJ catalyzes the glutamylation of bacterial ubiquitin ligases in a calmodulin-dependent manner.
    1. Microbiology and Infectious Disease

    Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program

    José Muñoz-Dorado et al.
    Investigation of global gene expression profiles during formation of the Myxococcus xanthus specialized biofilm reveals a genetic regulatory network that coordinates cell motility, differentiation, and secondary metabolite production.
    1. Neuroscience

    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

    Hongsheng Zhang et al.
    Enriched environment stimulates neuron generation in the hippocampus by a novel pathway involving Agrin, Lrp4, and Ror2.
    1. Cell Biology

    The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion

    Gareth W Fearnley et al.
    Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
    1. Cell Biology

    The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

    Diego Acosta-Alvear et al.
    The coordination of protein targeting to the endoplasmic reticulum and the unfolded protein response through the stress sensor IRE1 ensures quality control of the secreted and transmembrane proteomes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

    Ryan D Ferrao et al.
    An intracellular cytokine receptor 'switch' motif is critical for the dimerization of JAK2 and activation of the JAK2 kinase.
    1. Plant Biology

    Epidermal LysM receptor ensures robust symbiotic signalling in Lotus japonicus

    Eiichi Murakami et al.
    Functional analyses provide evidence for a complex Nod factor signalling where NFRe is necessary for maintaining an optimal symbiotic signalling in the susceptible root zone, and initiation of nodule primordia on the expanding root system.
    1. Cancer Biology
    2. Cell Biology

    Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

    Jeroen Claus et al.
    The clinically approved HER2 inhibitor lapatinib causes HER2 and HER3 kinase domains to dimerise in a non-canonical, symmetric orientation, providing a platform for oligomerisation and predisposing to receptor-driven cell proliferation.
    1. Plant Biology

    The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors

    Byoung Il Je et al.
    The maize CLAVATA receptor, FEA2, functions in the perception of two different ligands, and remarkably that signaling from these different inputs is differentiated by the receptor interacting with two different downstream components.
    1. Microbiology and Infectious Disease

    A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

    Sunil Kumar Dogga et al.
    An aspartyl protease is essential for the lytic cycle of Toxoplasma gondii and is involved in the maturation of proteins critical for invasion and egress, and it can be targeted selectively with an ethylamine scaffold based peptidomimetic inhibitor.

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