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    1. Developmental Biology

    Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates

    Michael W Susman et al.
    Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

    Luis Miguel Díaz-Santín et al.
    An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.
    1. Cell Biology

    RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

    Dianrong Li et al.
    Necroptosis triggers organ-specific, age-associated deterioration of male reproductive system.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Cancer Biology
    2. Cell Biology

    One reporter for in-cell activity profiling of majority of protein kinase oncogenes

    Iva Gudernova et al.
    A new luciferase and fluorescent reporter system enables rapid and efficient in-cell profiling of the majority of protein kinase oncogenes known to date.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of protein O-mannose kinase reveals a unique active site architecture

    Qinyu Zhu et al.
    Active site migration establishes kinase activity in protein O-mannose kinase.
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez et al.
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

    Robbyn L Weaver et al.
    Strengthening of spindle assembly checkpoint activity and attachment error correction through BubR1 manipulation preserves genomic integrity and protects against tumor formation.
    1. Stem Cells and Regenerative Medicine

    Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

    Rachel Lander, Christian P Petersen
    Signaling molecules expressed in overlapping body-wide transcriptional gradients determine central axis positional identity in whole-body regeneration.
    1. Biochemistry and Chemical Biology

    A secretory kinase complex regulates extracellular protein phosphorylation

    Jixin Cui et al.
    A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.