284 results found
    1. Neuroscience

    Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

    Valeria Oliva, Ron Hartley-Davies ... Jonathan CW Brooks
    Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.
    1. Neuroscience

    Cortico-striatal action control inherent of opponent cognitive-motivational styles

    Cassandra Avila, Martin Sarter
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo, Sabrina Totaro ... Corrado Corradi-Dell'Acqua
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
    1. Neuroscience

    Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

    Pablo M Casillas-Espinosa, Alison Anderson ... Terence J O'Brien
    Sodium selenate is the first treatment with persistent disease-modifying effects reducing seizures and improving cognitive deficits, in chronically epileptic and drug-resistant TLE animals.
    1. Neuroscience

    Neural signatures of auditory hypersensitivity following acoustic trauma

    Matthew McGill, Ariel E Hight ... Daniel B Polley
    Chronic two-photon calcium imaging, optogenetics, and operant behavioral approaches were leveraged to show that hyperactivity, hyperresponsivity, and hypersynchronization in auditory cortex neural ensembles can account for auditory hypersensitivity following acoustic trauma.
    1. Neuroscience

    Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation

    Sagi Jaffe-Dax, Or Frenkel, Merav Ahissar
    Implicit memory traces for recently encountered perceptual stimuli, including words, decay more quickly in people with dyslexia.
    1. Neuroscience

    Instructions and experiential learning have similar impacts on pain and pain-related brain responses but produce dissociations in value-based reversal learning

    Lauren Y Atlas, Troy C Dildine ... Daniel S Pine
    Combining computational models with FMRI in humans during pain reversal learning reveals parallel pain modulatory brain circuits that differ in their flexibility and sensitivity to instructions.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex

    Jose A Fernandez-Leon, Douglas S Engelke ... Fabricio H Do Monte
    A combination of electrophysiological and optogenetic approaches revealed a causal role for glutamatergic neurons in the prelimbic cortex in regulating individual differences in decision-making strategies during a threat-avoidance vs. reward-approach conflict paradigm in rats.
    1. Neuroscience

    Reward contingency gates selective cholinergic suppression of amygdala neurons

    Eyal Y Kimchi, Anthony Burgos-Robles ... Kay M Tye
    Electrophysiological recordings and optogenetic manipulations revealed the distinct roles that acetylcholine can have on the amygdala and prefrontal cortex in a Window of Opportunity Task.
    1. Biochemistry and Chemical Biology

    Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

    Yingjie Sun, Changheng Li ... Youngnam N Jin
    Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.

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