307 results found
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown et al.
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density

    Ward G Walkup IV et al.
    The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.
    1. Computational and Systems Biology
    2. Neuroscience

    A taxonomy of seizure dynamotypes

    Maria Luisa Saggio et al.
    Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.
    1. Biochemistry and Chemical Biology

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Simon Erlendsson et al.
    Investigations of binding of the scaffold protein PICK1 to transmembrane proteins in their native membrane environment demonstrate potent but slow dynamics and reveal distinct binding modes supporting different biological functions.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

    Nils Rademacher et al.
    Binding of ligands to PSD-95 PDZ domains induces a conformational change within the C-terminal domain module that enables differential binding to synaptic interactors.
    1. Neuroscience

    Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

    Rie Ishikawa et al.
    Forgetting of remote fear memory is promoted by increased hippocampal neurogenesis only after hippocampal reactivation by long time memory retrieval.
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu et al.
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu et al.
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Cell Biology

    The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

    Kanji Okumoto et al.
    H2O2-induced phosphorylation at Ser232 of Pex14 spatiotemporally regulates peroxisomal import of catalase, functioning in counteracting action against oxidative stress by the increase of cytosolic catalase.
    1. Neuroscience

    Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

    Yulan Li et al.
    A new strategy of memory consolidation disruption based on astrocyte and purinergic signaling, which leads to persistent fear memory attenuation accompanied by reduced fear-related anxiety behavior.

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