Investigation of global gene expression profiles during formation of the Myxococcus xanthus specialized biofilm reveals a genetic regulatory network that coordinates cell motility, differentiation, and secondary metabolite production.
ATP enters the endoplasmic reticulum (ER) lumen through an SLC35B1/AXER-dependentCaATiER mechanism, and ATP usage in the ER renders 'anti-Warburg' effect by increasing ATP regeneration from OxPhos while decreasing glycolysis.
The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
Having joined eLife in 2011, recruited and lead the staff team, Mark Patterson is planning to retire and leave his role as Executive Director at the end of this year. Here, he offers some personal perspectives on his time at eLife.
Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.