Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.
The concept of compound fracture risk is redefined to combine the risk that an individual will sustain a fracture and the risk of mortality once the fracture has occurred.
A three-dimensional investigation of extinct-tetrapod limbs shows that even though bone elongation and blood-cell production are intimately related to mammal long bones, these functions actually appeared successively in tetrapod evolution.
Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
Rudimentary cross-catalytic replication can be established by double-hairpins of tRNA-like sequences, implying that replication and translation could have emerged along a common evolutionary trajectory.
β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.
