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    1. Medicine

    Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

    Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Derivation and internal validation of prediction models for pulmonary hypertension risk assessment in a cohort inhabiting Tibet, China

    Junhui Tang, Rui Yang ... Yali Xu
    Prediction models for pulmonary hypertension based on a cohort inhabiting Tibet, China were established and validated.
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Cell Biology

    LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

    Kai Xu, Xiaoyue Pan ... Guoying Yu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    Chong Zhang, Zuoyan Zhang ... Yangling Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury

    Renaud Prével, Erwan Pernet ... Maziar Divangahi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine

    Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    Megan M Sperry, Berenice Charrez ... Donald E Ingber
    Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue injury.
    1. Cell Biology
    2. Immunology and Inflammation

    Arpin deficiency increases actomyosin contractility and vascular permeability

    Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor
    Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
    1. Immunology and Inflammation

    The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

    Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin
    The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
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