257 results found
    1. Chromosomes and Gene Expression

    Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

    Juan Manuel Povedano et al.
    Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Prediction of enzymatic pathways by integrative pathway mapping

    Sara Calhoun et al.
    A computational method identifies the functions of orphan enzymes by organizing them into metabolic pathways; the prediction of a new l-gulonate catabolic pathway is experimentally tested and confirmed.
    1. Human Biology and Medicine

    Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

    Mark G Jones et al.
    Nanoscale changes to individual collagen fibrils drive lung fibrosis.
    1. Cell Biology
    2. Human Biology and Medicine

    Automated cell-type classification in intact tissues by single-cell molecular profiling

    Monica Nagendran et al.
    The ability to rapidly stain for any combination of genes in intact tissue with automated quantification of transcripts in individual cells and spatial re-mapping affords new insights into lung biology, and will greatly accelerate progress in scientific and medical research.
    1. Computational and Systems Biology
    2. Neuroscience

    Rate and timing of cortical responses driven by separate sensory channels

    Hannes P Saal et al.
    Signals from different tactile submodalities are integrated optimally to culminate in cortical responses whose rate and timing conveys stimulus information.
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman et al.
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Ecology

    Sexual selection gradients change over time in a simultaneous hermaphrodite

    Jeroen NA Hoffer et al.
    The quantification of sexual selection reveals that it is important to consider the chosen time frame of measurement as well as the sexual system.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Lung Disease: The soot of all evil

    Derek W Russell, J Edwin Blalock
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  1. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez et al.
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.
    1. Neuroscience

    Chemoreception: Keeping carbon dioxide in check

    Alfredo J Garcia III, Jan-Marino Ramirez
    The response of the brainstem to increased levels of carbon dioxide in the blood is coordinated with the response of the cardiovascular system.
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