821 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

    Chi G Weindel et al.
    Long studied in the context of the central nervous system, LRRK2 also functions in peripheral immunity by maintaining mitochondrial homeostasis in macrophages to regulate the type I interferon response.
    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano et al.
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Neuroscience

    Downregulation of ribosome biogenesis during early forebrain development

    Kevin F Chau et al.
    Unbiased transcriptome analyses reveal that neural progenitor cells downregulate protein biosynthetic machinery during early forebrain development, and this fundamental process matches proteomic changes in the adjacent cerebrospinal fluid and is regulated in part by MYC.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

    Benjamin A Clarke et al.
    The ORMDL proteins function to restrain the de novo sphingolipid biosynthetic pathway during myelination, when there is a high demand for sphingolipids to prevent excessive accumulation of metabolic intermediates.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Parkinson’s Disease: Linking mitochondria to the immune response

    Rebecca L Wallings et al.
    A gene associated with Parkinson’s disease regulates mitochondrial homeostasis, thus affecting innate immunity.
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    1. Developmental Biology
    Ciona intestinalis illustration

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Ecology
    2. Plant Biology
    Arabidopsis illustration

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Evolutionary Biology
    2. Plant Biology

    Ascorbate Biosynthesis: A cross-kingdom history

    Alisdair R Fernie, Takayuki Tohge
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    1. Biochemistry and Chemical Biology

    Gene Regulation: Acting in tandem

    Robert A Battaglia, Ailong Ke
    RNA structures called tandem riboswitches allow bacteria to employ complex logical operations in response to nutrient starvation.
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