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A murine model of sepsis shows that the purinergic P2X7 receptor controls the release of CD14 in extracellular vesicles playing a key role in cytokine production, bacterial clearance, and survival.

Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.

Genetic and biochemical analyses demonstrate that cell-surface lectin receptors can potentially function as extracellular NAD⁺-binding receptors and provide direct evidence for extracellular NAD⁺ being a bona fide endogenous signaling molecule in plants.

Sweet and umami taste receptors are capable of sensing chloride ions, a component of table salt other than the salty taste-inducing component, sodium ions, and induce preferable taste sensations such as sweet taste.

Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO₂/H+-dependent disinhibition.

Apoptotic cells release molecules to recruit macrophages, but do not cause inflammation because they also secrete AMP that functions as a ‘calm down’ signal.

Rab11a-mediated endosomal trafficking in macrophages regulates potassium channel localization and activity at the cell surface and the downstream activation of the inflammasome and is a potential therapeutic target in acute or chronic inflammatory states.

An in vivo drug screen of FDA-approved compounds in zebrafish identified host-directed therapies against mycobacterial infection, including the drug clemastine, which targets the P2RX7-inflammasome axis to enhance bacterial control.

TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.

A new pathway is described involving the estrogen receptor alpha in the acute response of small arteries to flow independent of the ligand (estrogen) and of the nuclear signaling.