487 results found
    1. Neuroscience

    Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses

    Patricia M Horvath et al.
    GABAergic postsynaptic responses mediated by spontaneous and evoked neurotransmitter release are partially segregated, suggesting they may serve distinct roles in neuronal signaling.
    1. Neuroscience

    Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance

    Su Hong et al.
    Neuromodulation of the expression of Hebbian plasticity enables rapid cortical sensory-induced remodeling in post-critical period adults, and can rescue deficits induced by prolonged sensory deprivation.
    1. Neuroscience

    Alterations in the amplitude and burst rate of beta oscillations impair reward-dependent motor learning in anxiety

    Sebastian Sporn et al.
    State anxiety alters the dynamics of beta oscillations during reward-dependent motor learning, thereby impairing proper updating of motor predictions when learning in unstable environments.
    1. Neuroscience

    Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons

    Hiroki Ito et al.
    Ponto-spinal CRH neurons in Barrington’s nucleus are a core component of an inferential circuit that regulates autonomous micturition and generates voids when the bladder is full.
    1. Neuroscience

    Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior

    James M Mossner et al.
    Loss of function of the Rett syndrome gene MeCP2 in a small but powerful interneuron population, the VIP cells, causes a unique combination of impairments in neural function and behavior.
    1. Neuroscience

    Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

    Sadra Sadeh, Claudia Clopath
    Neuronal networks with strong functional specificity of connections between excitatory and inhibitory neurons show specific dynamics of inhibitory stabilization, accompanied with rapid spontaneous activity transitions between highly selective functional states.
    1. Neuroscience

    Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation

    Mathieu Letellier et al.
    Orthogonal to traditional paradigms that manipulate neuroligin expression level, optogenetic stimulation of tyrosine phosphorylation highlights a role of the intracellular domain of endogenous neuroligin-1 in excitatory synaptic differentiation and potentiation.
    1. Computational and Systems Biology
    2. Neuroscience

    Theoretical relation between axon initial segment geometry and excitability

    Sarah Goethals, Romain Brette
    Theoretical analysis uncovers the impact of axon initial segment plasticity on neural excitability.
    1. Neuroscience

    A calibrated optogenetic toolbox of stable zebrafish opsin lines

    Paride Antinucci et al.
    Generation of stable transgenic opsin lines together with in vivo calibration of their efficacy using behavioural and electrophysiological assays constitutes a novel optogenetic toolkit in zebrafish.

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