CD40-activated CD40L-mediated reverse signalling has strikingly opposite effects on the growth of excitatory and inhibitory neuron dendrites in the developing brain of mice.
New evidence challenges the long-held view that motor cortex lacks a fourth layer, and reveals that its circuitry resembles that of other cortical regions more than previously thought.
Layer 5 neuron apical tuft in mouse visual cortex display widespread, highly correlated calcium signals, with a strong and asymmetric coupling to somatic signals, independent of visual stimulation and locomotion.
The medial entorhinal cortex is important for spatial memory formation and matures from dorsal, where smaller spatial-scales are represented, to ventral, where larger spatial-scales are represented.
NMDA receptors on PV+ interneurons mediate supralinear integration at feedback synapses from local pyramidal neurons, enabling competing networks to ‘lock’ onto salient inputs.
In motor cortex pyramidal neurons, diverse task-related signals are distributed throughout the dendritic arbor and compartmentalized by dendritic distance and branching.
Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
