235 results found
    1. Cell Biology

    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

    Minseong Kim et al.
    HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

    Yao Rong et al.
    Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan et al.
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

    Lizhi He et al.
    YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
    1. Biochemistry and Chemical Biology

    Witnessing the structural evolution of an RNA enzyme

    Xavier Portillo et al.
    An RNA enzyme is caught in the act of evolving a new structural domain within its active site, resulting in enhanced catalytic function.
    1. Neuroscience

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

    Silvia Leon et al.
    The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

    Satoshi Takahashi et al.
    Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian et al.
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.

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