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    1. Immunology and Inflammation

    Gamma delta T cells recognize haptens and mount a hapten-specific response

    Xun Zeng et al.
    The T-cell receptors of gamma delta (γδ) T cells can recognize and trigger responses to small molecules and are thereby versatile drivers of immunity.
    1. Biochemistry and Chemical Biology

    Gene Regulation: Acting in tandem

    Robert A Battaglia, Ailong Ke
    RNA structures called tandem riboswitches allow bacteria to employ complex logical operations in response to nutrient starvation.
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    1. Microbiology and Infectious Disease

    Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

    Megan Okada et al.
    Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

    Mareike Bongers et al.
    Differences in HDR product preference present a novel mechanism in plants to control substrate availability for short- and long-chain isoprenoids.
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt et al.
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers et al.
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

    Friso S Aalbers et al.
    By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.
    1. Immunology and Inflammation

    IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

    Qian Wang et al.
    Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat et al.
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.