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Page 2 of 202
    1. Neuroscience

    Characterization of direct Purkinje cell outputs to the brainstem

    Christopher H Chen, Zhiyi Yao ... Wade G Regehr
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

    Kira A Cozzolino, Lynn Sanford ... Dylan J Taatjes
    The Mediator-associated kinases CDK8 and CDK19 help drive inflammatory responses to interferon, and it is discovered that kinase-dependent transcriptional responses manifest in part through splicing changes and lipid metabolites.
    1. Cell Biology
    2. Cancer Biology

    Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Developmental Biology

    Oviductin sets the species-specificity of the mammalian zona pellucida

    Daniel de la Fuente, Maria Maroto ... Alfonso Gutiérrez-Adán
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G.-J Sterckx
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

    Ainhoa Arbués, Sarah Schmidiger ... Damien Portevin
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Medicine

    Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
    1. Neuroscience

    Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of cerebellar Purkinje cells

    Takuma Inoshita, Shin-ya Kawaguchi
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

    Mathias Guayasamin, Lewis R Depaauw-Holt ... Ciaran Murphy-Royal
    Amygdala astrocytes play a critical role in mediating the effects of stress during infancy on neuronal excitability, synaptic plasticity, and memory.
    1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    Timely vaccine strain selection and genomic surveillance improves evolutionary forecast accuracy of seasonal influenza A/H3N2

    John Huddleston, Trevor Bedford
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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